Eosinophilic Granuloma: Understanding the Condition
Eosinophilic Granuloma: Understanding the Condition Eosinophilic granuloma, also known as Langerhans cell histiocytosis, is a rare disorder that primarily affects the bones. It is crucial to have a comprehensive understanding of this condition to effectively manage and treat it.
At Acibadem Healthcare Group, we recognize the importance of awareness and knowledge when it comes to eosinophilic granuloma. That’s why we have dedicated resources and expertise to advance the understanding of this condition and provide exceptional care to our patients.
By increasing awareness and understanding of eosinophilic granuloma, we aim to empower individuals and healthcare professionals to make well-informed decisions and provide the best possible care for those affected by this condition.
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Eosinophilic Granuloma: What is it?
Eosinophilic granuloma is a rare disorder that primarily affects bones, causing the development of bone lesions. It is a form of Langerhans cell histiocytosis, characterized by the accumulation of abnormal immune cells called eosinophils in the affected areas. These lesions can occur in any bone, but they most commonly affect the skull, mandible, ribs, spine, and long bones of the arms and legs.
The Pathology of Eosinophilic Granuloma
Eosinophilic granuloma is characterized by the proliferation of Langerhans cells, a type of dendritic cell, in the bone tissue. These abnormal cells infiltrate the bone marrow, leading to the formation of granulomas, which are collections of immune cells and fibrous tissue. Within these granulomas, eosinophils, a type of white blood cell, are often present. The exact cause of eosinophilic granuloma is unknown, but it is believed to involve a combination of genetic predisposition and immune system dysfunction.
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Early detection and diagnosis of eosinophilic granuloma are essential for effective management. Diagnostic procedures may include imaging tests such as X-rays, CT scans, or MRI scans to identify bone lesions and characterize their extent. Biopsy may also be performed to confirm the presence of eosinophilic granuloma by examining the affected tissue under a microscope.
Treatment options for eosinophilic granuloma depend on the location and severity of the bone lesions, as well as the symptoms experienced by the individual. In some cases, conservative management approaches, such as pain medication and physical therapy, may be sufficient. However, more aggressive treatments, such as surgical removal of the lesion or radiation therapy, may be necessary to alleviate pain and prevent further damage to the bone.
In conclusion, eosinophilic granuloma is a rare disorder characterized by the development of bone lesions. Understanding the pathology of the disease and recognizing its signs and symptoms are crucial for early detection and effective management. By utilizing appropriate diagnostic tools and considering individualized treatment approaches, healthcare professionals can improve the quality of life for individuals with eosinophilic granuloma.
Causes and Risk Factors of Eosinophilic Granuloma
Eosinophilic granuloma is a rare condition that primarily affects the bones. Understanding the potential causes and risk factors associated with this condition is crucial in developing effective management strategies. Furthermore, exploring the link between eosinophilic granuloma and other diseases such as ECD and Hand-Schuller-Christian disease can provide valuable insights into its pathogenesis and progression.
The specific etiology of eosinophilic granuloma is still under investigation. However, it is believed to involve a combination of genetic and environmental factors. Certain gene mutations and alterations have been associated with an increased risk of developing eosinophilic granuloma, including the BRAF V600E mutation. This mutation, commonly found in Langerhans cell histiocytosis (LCH), has been observed in some cases of eosinophilic granuloma as well.
The BRAF V600E mutation leads to abnormal activation of a cellular signaling pathway that promotes cell growth and division. This dysregulated signaling may contribute to the formation of bone lesions characteristic of eosinophilic granuloma. It is important to note that not all cases of eosinophilic granuloma are associated with the BRAF V600E mutation, highlighting the complex and multifactorial nature of this condition.
In addition to genetic factors, certain environmental triggers may play a role in the development of eosinophilic granuloma. Exposure to certain chemicals, toxins, or infections has been suggested as potential risk factors. However, the exact mechanisms by which these factors contribute to the development of the condition are still not fully understood.
Understanding the interplay between genetic susceptibility, environmental factors, and the development of eosinophilic granuloma is essential for accurate diagnosis and effective management. By identifying and addressing these underlying causes and risk factors, healthcare professionals can tailor treatment plans to meet the specific needs of each individual.
Further research is needed to unravel the intricate mechanisms of eosinophilic granuloma and its link with other diseases. By expanding our knowledge, we can enhance early detection, improve treatment outcomes, and ultimately improve the quality of life for individuals living with this rare condition.
Symptoms and Diagnosis of Eosinophilic Granuloma
Eosinophilic granuloma can manifest in a variety of symptoms, which can vary depending on the location and extent of bone lesions. Recognizing these symptoms is crucial for early diagnosis and treatment. Common signs of eosinophilic granuloma include:
- Pain: Bone pain is a frequent symptom of eosinophilic granuloma, particularly in areas affected by bone lesions. The pain may worsen with movement or pressure.
- Swelling: Bone lesions caused by eosinophilic granuloma can lead to localized swelling or a lump in the affected area.
- Restricted Mobility: Depending on the location and size of the bone lesions, eosinophilic granuloma can impede joint movement, leading to decreased mobility.
- Fracture: In severe cases of eosinophilic granuloma, bone lesions can weaken the structure of the affected bone, increasing the risk of fractures.
To diagnose eosinophilic granuloma, healthcare professionals employ various diagnostic procedures and tests to confirm the presence of the condition:
- Medical History and Physical Examination: Physicians will gather information about the patient’s medical history and perform a thorough physical examination to assess the symptoms and identify any visible bone lesions.
- Imaging Tests: X-rays, CT scans, and MRI scans are commonly used to visualize bone lesions and assess the extent of the disease. These imaging techniques help healthcare professionals determine the location, size, and number of bone lesions present.
- Biopsy: A tissue biopsy is often performed to confirm the diagnosis of eosinophilic granuloma. During this procedure, a small sample of the affected bone tissue is collected and examined under a microscope to identify the characteristic features of eosinophilic granuloma.
- Additional Tests: In some cases, additional tests such as blood tests or bone scans may be recommended to rule out other conditions or assess the overall health status of the patient.
Early diagnosis and prompt treatment of eosinophilic granuloma are essential to prevent further damage to the affected bones and improve the patient’s overall quality of life.
| Common Symptoms of Eosinophilic Granuloma | Diagnostic Procedures and Tests |
|---|---|
| Pain | Medical History and Physical Examination |
| Swelling | Imaging Tests |
| Restricted Mobility | Biopsy |
| Fracture | Additional Tests |
Treatment Options for Eosinophilic Granuloma
When it comes to managing eosinophilic granuloma, there are various treatment options available for patients. The choice of treatment depends on several factors, such as the severity of the condition, the location of the lesions, and the specific needs of each individual. Here, we will explore the different approaches to treating eosinophilic granuloma, including medication, surgery, and other therapeutic interventions.
1. Medication
Medication plays a crucial role in controlling the symptoms and progression of eosinophilic granuloma. Depending on the individual case, a healthcare professional may prescribe anti-inflammatory drugs, immunosuppressants, or targeted therapy. These medications aim to reduce inflammation, alleviate pain, and inhibit the growth of granulomas.
2. Surgery
In some cases, surgery may be necessary to treat eosinophilic granuloma. The decision for surgery is typically made when the lesions pose a risk to nearby structures, cause functional impairment, or result in significant pain. Surgical procedures can include curettage (the removal of the affected bone tissue) or bone grafting (replacing the removed tissue with healthy bone).
3. Other Therapeutic Interventions
In addition to medication and surgery, other therapeutic interventions may be employed to manage eosinophilic granuloma. These can include radiation therapy, which targets and destroys the abnormal cells, or embolization, a procedure that cuts off the blood supply to the granulomas, preventing further growth.
The choice of treatment will be determined in consultation with a healthcare professional, taking into account the patient’s overall health, preferences, and specific circumstances. A personalized treatment plan will ensure the most effective approach to managing eosinophilic granuloma and improving the patient’s quality of life.
At Acibadem Healthcare Group, we specialize in providing comprehensive care and treatment for patients with eosinophilic granuloma. Our experienced medical team combines expertise with the latest technology to deliver personalized treatment plans that address the unique needs of each individual. By staying at the forefront of medical advancements, we strive to offer the most innovative treatment options and ensure the best possible outcomes for our patients.
Management and Lifestyle Modifications for Eosinophilic Granuloma
Effectively managing eosinophilic granuloma involves adopting specific strategies and making certain lifestyle modifications that can contribute to overall well-being. By incorporating these recommendations, individuals with eosinophilic granuloma can enhance their quality of life and minimize the impact of bone lesions caused by this condition.
Physical Activity
Engaging in regular physical activity is crucial for individuals with eosinophilic granuloma. Although the intensity and type of exercise may vary depending on individual circumstances, the benefits of physical activity include improved bone health, increased muscle strength, enhanced flexibility, and a boost in overall fitness.
It is advisable to consult with a healthcare professional, such as a physiotherapist or sports medicine specialist, to develop a personalized exercise plan that takes into consideration any limitations or specific needs associated with eosinophilic granuloma. This ensures that physical activities are safe, enjoyable, and tailored to each person’s unique circumstances.
Nutrition
Adopting a balanced and nutritious diet is paramount for individuals with eosinophilic granuloma. Consuming a variety of nutrient-rich foods can support bone health, strengthen the immune system, and promote overall well-being.
Some key dietary considerations for individuals with eosinophilic granuloma include:
- Ensuring an adequate intake of calcium and vitamin D to support bone health.
- Incorporating sources of lean protein, such as fish, poultry, legumes, and tofu, to support muscle growth and repair.
- Including plenty of fruits and vegetables to provide essential vitamins, minerals, and antioxidants.
- Avoiding or limiting processed foods, sugary beverages, and excessive salt intake, as these can negatively affect overall health and potentially exacerbate symptoms.
Ongoing Medical Care
Regular medical care and monitoring are essential for effectively managing eosinophilic granuloma. This includes scheduled follow-up visits with healthcare professionals specializing in bone disorders or oncology.
During these visits, the healthcare team will assess the progression of eosinophilic granuloma, monitor bone lesions, and discuss any changes in symptoms or overall health. They may recommend additional diagnostic tests, adjustments to the treatment plan, or referrals to specialists as needed.
Emotional Support
Living with eosinophilic granuloma can be emotionally challenging, as it may bring about fears, uncertainties, and limitations. Seeking emotional support from healthcare professionals, family, friends, or support groups can be instrumental in managing the psychological impact of this condition.
Counseling or therapy sessions may also be beneficial, helping individuals cope with the emotional aspects of the disease and develop effective strategies for managing stress and anxiety.
Understanding the BRAF V600E Mutation and Eosinophilic Granuloma
In recent years, researchers have made significant progress in unraveling the complex mechanisms underlying eosinophilic granuloma. One noteworthy discovery involves the link between the BRAF V600E mutation and the development and progression of this condition.
The BRAF V600E mutation is a specific genetic alteration that occurs in certain cells of the body, including Langerhans cells, which are involved in the immune response. Studies have identified the BRAF V600E mutation in a significant proportion of eosinophilic granuloma cases. This finding has shed light on the underlying molecular processes driving the disease.
The presence of the BRAF V600E mutation leads to the activation of specific signaling pathways within cells, promoting uncontrolled cell growth and proliferation. This abnormal cellular activity contributes to the formation of eosinophilic granuloma lesions, primarily affecting the bones. The identification of this mutation has not only enhanced our understanding of the disease but also provided potential avenues for targeted therapies.
To better comprehend the implications of the BRAF V600E mutation in eosinophilic granuloma, ongoing research is focused on investigating the precise interactions between the mutation and the surrounding cellular microenvironment. By gaining insights into the molecular mechanisms at play, scientists hope to identify novel treatment approaches and develop personalized therapies that specifically target the mutated cells.
The Role of Targeted Therapies:
Targeted therapies have emerged as a promising avenue for the treatment of cancers and other genetic disorders. In the context of eosinophilic granuloma, researchers are exploring the potential of targeting the BRAF V600E mutation to halt the disease progression.
Several clinical trials are currently underway to evaluate the efficacy and safety of BRAF inhibitors, which are designed to block the activity of the mutant protein in cells. Preliminary results have shown promising outcomes in reducing the size of eosinophilic granuloma lesions and alleviating symptoms in patients with the BRAF V600E mutation.
| Treatment Approach | Advantages | Challenges |
|---|---|---|
| BRAF Inhibitors | – Specifically targets the BRAF V600E mutation – Promising initial results – May reduce lesion size and improve symptoms |
– Limited long-term data – Side effects and potential resistance |
| Combination Therapies | – Targets multiple signaling pathways – Enhances efficacy |
– Complex treatment protocols – Potential for increased toxicity |
| Immunotherapies | – Harnesses the immune system – Potential for long-term remission |
– Limited data in eosinophilic granuloma – Response variability |
While targeted therapies hold great promise, it is important to note that individual responses may vary. Factors such as the extent of the disease, overall health, and genetic variations can influence treatment outcomes. Therefore, personalized approaches tailored to each patient’s specific characteristics and needs are crucial for optimizing treatment success.
As research in this field continues to evolve, the identification of the BRAF V600E mutation has provided a valuable foundation for understanding eosinophilic granuloma. With ongoing advancements in targeted therapies, there is hope for improved treatment outcomes and better management of this rare condition.
Eosinophilic Granuloma and Histiocytic Sarcoma: Exploring the Connection
When it comes to understanding eosinophilic granuloma, it is important to explore its connection with histiocytic sarcoma. While these two conditions are distinct, they share similarities in terms of their rare occurrence and cancerous nature.
Eosinophilic granuloma primarily affects bones, leading to the formation of lesions. On the other hand, histiocytic sarcoma is a rare form of cancerous growth that can develop in various tissues throughout the body.
Recent research suggests that there may be a link between eosinophilic granuloma and the development of histiocytic sarcoma. Some studies have found shared genetic alterations and overlapping histopathological features in these conditions, indicating a potential connection between the two.
Understanding this association between eosinophilic granuloma and histiocytic sarcoma is crucial for better management and treatment decisions. It can help healthcare professionals tailor their approach to provide the most appropriate care for patients facing these rare conditions.
By delving deeper into the relationship between eosinophilic granuloma and histiocytic sarcoma, researchers and medical practitioners hope to uncover insights that could lead to improved treatment options and outcomes for individuals affected by these conditions.
| Eosinophilic Granuloma | Histiocytic Sarcoma |
|---|---|
| Primarily affects bones | Can develop in various tissues throughout the body |
| Formation of bone lesions | Rare form of cancerous growth |
| Shared genetic alterations | Overlapping histopathological features |
| Crucial for management and treatment decisions | Can help tailor care for patients |
Lymph Nodes and Eosinophilic Granuloma: What You Need to Know
Eosinophilic granuloma, a rare bone disorder, can also impact lymph nodes, vital structures of the immune system. Understanding this connection is crucial for a comprehensive understanding of the disease’s impact on overall health.
Eosinophilic Granuloma and Lymph Nodes: An Interplay of Cells
Eosinophilic granuloma involves an abnormal proliferation of Langerhans cells, a type of immune cell. These cells can infiltrate lymph nodes and cause localized lymphadenopathy, leading to swelling and tenderness in affected regions. This involvement of lymph nodes further influences the disease progression and treatment approach.
Implications on Diagnosis and Staging
The presence and assessment of lymph node involvement are important factors in the diagnosis and staging of eosinophilic granuloma. Detecting enlarged lymph nodes through imaging studies, such as CT scans or MRI, can aid in accurately determining the extent of the disease and planning appropriate treatment strategies.
Treatment Considerations
When eosinophilic granuloma affects lymph nodes, treatment decisions may need to be adjusted accordingly. Surgical excision of involved lymph nodes, along with other treatment modalities like chemotherapy or immunotherapy, may be required to achieve optimal outcomes.
Monitoring and Follow-up Care
Regular monitoring of lymph nodes is crucial in managing eosinophilic granuloma. Periodic imaging and clinical evaluation can help gauge the response to treatment and monitor for recurrence or progression of the disease within the lymph node regions.
| Key Points | Implications |
|---|---|
| Eosinophilic granuloma can affect lymph nodes. | Understanding lymph node involvement is essential for accurate diagnosis and staging. |
| Eosinophilic granuloma-induced lymphadenopathy can cause swelling and tenderness. | Proper management of lymph node symptoms is crucial for improving patient comfort. |
| Lymph node imaging and clinical evaluation are necessary for monitoring treatment response. | Regular follow-up enables timely interventions and reduces the risk of disease progression. |
CD1a Expression and Eosinophilic Granuloma: Unraveling the Mechanisms
CD1a expression and dendritic cells play a crucial role in the development and progression of eosinophilic granuloma. These mechanisms offer valuable insights into potential treatment approaches for this rare condition.
Eosinophilic granuloma is characterized by the presence of abnormal proliferating Langerhans cells, a type of dendritic cell, in affected tissues, particularly bones. These cells exhibit CD1a expression, a protein marker that helps identify Langerhans cells. CD1a is involved in antigen presentation, immune response regulation, and cell-to-cell communication.
The abnormal CD1a expression and dysfunction of dendritic cells in eosinophilic granuloma contribute to the accumulation of inflammatory cells and the formation of granulomas, which are clusters of immune cells. These granulomas can damage surrounding tissues, leading to symptoms such as pain, swelling, and restricted mobility.
By understanding the mechanisms underlying CD1a expression and dendritic cell dysfunction in eosinophilic granuloma, researchers and healthcare professionals are exploring targeted treatment approaches. One potential avenue is the development of therapies that modulate CD1a expression or promote the normal functioning of dendritic cells. By restoring the balance of immune cell activity, these treatments aim to reduce inflammation and halt the progression of the disease.
Current Research and Future Directions
The investigation of CD1a expression and dendritic cell function in eosinophilic granuloma is an active area of research. Ongoing studies aim to further elucidate the specific molecular mechanisms involved and explore novel therapeutic strategies.
A comprehensive understanding of the interaction between CD1a expression, dendritic cells, and eosinophilic granuloma will pave the way for more precise and effective treatment options. The ultimate goal is to develop targeted therapies that can alleviate symptoms, prevent disease progression, and improve overall patient outcomes.
| Treatment Approaches | Potential Benefits |
|---|---|
| Targeting CD1a expression | Modulate abnormal immune response |
| Promoting dendritic cell function | Restore immune homeostasis |
| Immunotherapy | Enhance the body’s immune response |
| Radiation therapy | Target and shrink tumor-like lesions |
Overall, the exploration of CD1a expression and dendritic cell function in eosinophilic granuloma holds promise for improved understanding and management of this rare condition. Through continued research efforts, we can hope for innovative treatments that provide relief and enhance the quality of life for individuals affected by eosinophilic granuloma.
Eosinophilic Granuloma Research and Advancements
In the field of eosinophilic granuloma, ongoing research and advancements play a crucial role in deepening our understanding of this rare condition. Through dedicated studies and innovative treatment options, institutions like Acibadem Healthcare Group are at the forefront of driving progress in eosinophilic granuloma management.
Research efforts are focused on unraveling the underlying mechanisms of eosinophilic granuloma, enhancing diagnostic techniques, and exploring new therapeutic approaches. Ongoing studies aim to identify genetic markers, such as the BRAF V600E mutation, that may contribute to the development and progression of the condition.
Advancements in Diagnostic Imaging
One area of advancement lies in diagnostic imaging techniques. High-resolution imaging, such as X-rays, computed tomography (CT) scans, and magnetic resonance imaging (MRI), has revolutionized the detection of eosinophilic granuloma and bone lesions. These non-invasive imaging modalities enable healthcare professionals to accurately visualize the affected areas, aiding in early diagnosis and precise treatment planning.
Furthermore, advances in positron emission tomography (PET) imaging have shown promise in identifying active lesions and monitoring treatment response. This cutting-edge technology provides valuable insights into disease activity and progression, assisting in the evaluation of treatment efficacy and disease monitoring over time.
Innovative Treatment Approaches
The development of innovative treatment strategies is an essential area of focus in eosinophilic granuloma research. Acibadem Healthcare Group, alongside other leading institutions, continues to explore novel therapeutic agents and approaches to improve patient outcomes.
Immunomodulatory therapies, such as interferon alpha and targeted biological therapies, have shown promising results in managing eosinophilic granuloma. These treatments aim to modulate the immune system and target specific pathways involved in the development of the disease.
Researchers are also investigating the potential of personalized medicine in the treatment of eosinophilic granuloma. By identifying molecular characteristics and genetic profiles unique to each patient, personalized treatment plans can be crafted to provide more targeted and effective care.
Collaborative Efforts and Knowledge Sharing
Achieving advancements in eosinophilic granuloma research necessitates collaboration among healthcare professionals, researchers, and institutions. Acibadem Healthcare Group actively participates in scientific conferences, symposia, and research forums to foster knowledge sharing and facilitate interdisciplinary collaborations.
Through these collaborative efforts, experts in the field can exchange ideas, discuss recent findings, and work together to develop evidence-based guidelines and treatment protocols. This collective approach accelerates progress and ultimately improves outcomes for individuals living with eosinophilic granuloma.
In Summary, ongoing research and advancements in eosinophilic granuloma are instrumental in expanding our knowledge and improving the management of this rare condition. Institutions like Acibadem Healthcare Group are at the forefront of these efforts, driving innovation and facilitating collaborative research for better patient outcomes.
Conclusion
In conclusion, this article has provided an in-depth exploration of eosinophilic granuloma, a rare condition primarily affecting bone lesions. By examining its causes, symptoms, diagnosis, treatment options, and management strategies, we have aimed to increase awareness and knowledge surrounding this condition. This information can empower individuals and healthcare professionals in effectively addressing eosinophilic granuloma and improving patient outcomes.
Eosinophilic granuloma, characterized by abnormal growths in bone tissue, requires early detection and proper management to prevent complications. Through this article, we have emphasized the importance of understanding the pathology behind this condition, including the association with the BRAF V600E mutation and the connection to histiocytic sarcoma.Eosinophilic Granuloma: Understanding the Condition
Various treatment options, such as medication, surgery, and lifestyle modifications, can help manage eosinophilic granuloma and improve the quality of life for those affected. Ongoing research and advancements, led by institutions like the renowned Acibadem Healthcare Group, continue to enhance our understanding of this condition and offer hope for future breakthroughs.
FAQ
What is eosinophilic granuloma?
Eosinophilic granuloma is a rare disorder that primarily affects bones, causing bone lesions.
What are the causes and risk factors of eosinophilic granuloma?
The exact causes of eosinophilic granuloma are unknown, but it is believed to be associated with conditions such as ECD and Hand-Schuller-Christian disease.
What are the common symptoms and how is eosinophilic granuloma diagnosed?
Common symptoms of eosinophilic granuloma include pain, swelling, and restricted mobility. Diagnosis is typically made through imaging tests such as X-rays or bone scans.
Conclusion
This article has provided an in-depth exploration of eosinophilic granuloma, including its causes, symptoms, diagnosis, treatment options, and management strategies, aimed at empowering individuals and healthcare professionals in addressing this rare condition.
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