Epidermolysis Bullosa Acquisita
Epidermolysis Bullosa Acquisita Epidermolysis bullosa acquisita (EBA) is a rare and debilitating autoimmune skin disorder, characterized by blistering and fragility of the skin. This chronic condition affects individuals of all ages, causing significant discomfort and impacting their quality of life.
At Acibadem Healthcare Group, we understand the challenges faced by those living with EBA. Our team of experienced dermatologists specializes in the diagnosis and management of this unique skin condition. With our expertise and cutting-edge treatments, we aim to provide comprehensive care and support to individuals with EB acquisita.
As a blistering skin disorder, EBA can lead to painful blisters and erosions on the skin and mucous membranes. The exact cause of this autoimmune disease is still not fully understood, but it is believed to involve an abnormal immune response targeting the skin’s own proteins.
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We believe that everyone deserves access to quality healthcare, which is why we have established multiple branches in strategic locations. Whether you're in need of routine check-ups, specialized treatments, or emergency care, ACIBADEM Health Point is here for you.Diagnosing epidermolysis bullosa acquisita requires a multidisciplinary approach, with dermatologists playing a crucial role in assessing the clinical presentation and conducting various diagnostic tests. These may include skin biopsies, immunofluorescence studies, and blood tests to confirm the diagnosis and determine the specific subtype of EBA.
Treatment options for EBA vary depending on the severity and extent of the disease. Our dermatologists may recommend a combination of systemic medications, such as immunosuppressants, and topical therapies to manage the symptoms and prevent further complications.
Living with a rare disease like epidermolysis bullosa acquisita can be challenging, both physically and emotionally. That’s why we strive to provide ongoing support and resources to help patients cope with the impact of this chronic condition. From patient support groups to online communities, we are here to ensure that no one with EBA has to face their journey alone.
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ACIBADEM Health Point, we are dedicated to providing exceptional healthcare services to our patients. With a team of highly skilled medical professionals and state-of-the-art facilities, we strive to deliver the highest standard of care to improve the health and well-being of our patients. What sets ACIBADEM Health Point apart is our patient-centered approach. We prioritize your comfort, safety, and satisfaction throughout your healthcare journey. Our compassionate staff ensures that you receive personalized care tailored to your unique needs, making your experience with us as seamless and comfortable as possible.In conclusion, epidermolysis bullosa acquisita is a rare and complex blistering skin disorder that requires specialized care and expertise. At Acibadem Healthcare Group, we are committed to providing comprehensive diagnostic services, individualized treatment plans, and ongoing support for individuals with this debilitating autoimmune disease.
Understanding Epidermolysis Bullosa Acquisita
Epidermolysis bullosa acquisita (EBA) is an autoimmune disease that primarily affects the skin, leading to the development of blisters. This chronic skin condition falls under the category of blistering disorders, characterized by the fragile nature of the skin and its propensity to blister even with minimal trauma.
Individuals with EBA often experience painful blisters and erosions on the skin, which can occur in various areas of the body. The blistering in EBA is a result of the immune system mistakenly attacking the proteins that hold the layers of the skin together, leading to a loss of structural integrity.
The symptoms of EBA can vary from mild to severe, and may include:
- Blister formation
- Widespread skin erosions
- Scarring
- Itching
- Pain or discomfort
The exact cause of EBA is still unknown, but it is believed to be a complex interplay of genetic and environmental factors. It is classified as a rare disease, affecting a small percentage of the population.
Several risk factors have been associated with the development of EBA, including:
- Genetic predisposition
- Autoimmune disorders
- Infections
- Medications
Diagnosing EBA requires a thorough evaluation by dermatologists who specialize in autoimmune skin disorders. This often involves a physical examination, review of medical history, and various tests such as skin biopsies and blood work.
Early diagnosis and proper management are crucial for individuals with EBA to alleviate symptoms, prevent complications, and improve quality of life. There are various treatment options available, including immunosuppressive medications and wound care strategies to promote healing and reduce further damage to the skin.
Living with Epidermolysis Bullosa Acquisita
Living with EBA can present numerous challenges, both physical and emotional. The chronic nature of the disease, along with the constant blistering and pain, can have a significant impact on daily life. It is important for individuals with EBA to establish a support system and access resources that can provide guidance, education, and emotional support.
By understanding the complexities of epidermolysis bullosa acquisita and seeking appropriate medical care, individuals affected by this autoimmune skin condition can better manage their symptoms and improve their overall quality of life.
Types of Epidermolysis Bullosa Acquisita
Epidermolysis bullosa acquisita (EBA) is a rare and complex skin condition characterized by blistering of the skin. There are different types of EBA, each with its own distinct characteristics and presentation.
Junctional EBA
Junctional EBA is a subtype of EBA that primarily affects the junction between the epidermis and the basement membrane. It is characterized by blistering and erosion in the mucous membranes, as well as the skin. Junctional EBA is often associated with scarring and can lead to severe complications.
Dystrophic EBA
Dystrophic EBA is another subtype of EBA that affects mainly the anchoring fibrils within the dermal-epidermal junction. It is characterized by blistering, erosions, and scarring. Dystrophic EBA can also involve other mucous membranes, such as the eyes and the gastrointestinal tract.
Inflammatory EBA
Inflammatory EBA is a subtype of EBA that presents with intense inflammation in addition to blistering and erosion. This type of EBA often resembles other autoimmune blistering disorders, making diagnosis challenging. Inflammatory EBA is associated with systemic involvement and may require more aggressive treatment approaches.
Other Subtypes
In addition to the above subtypes, there are rare variants and subtypes of EBA that have been reported in the literature. These include the mechanobullous or herpetiform variant, as well as the childhood-onset variant. These subtypes further highlight the complexity and heterogeneity of EBA.
| Type of EBA | Description |
|---|---|
| Junctional EBA | Affects the junction between the epidermis and basement membrane, leading to blistering and erosion in mucous membranes and skin |
| Dystrophic EBA | Affects the anchoring fibrils within the dermal-epidermal junction, causing blistering, erosions, and scarring |
| Inflammatory EBA | Presents with intense inflammation in addition to blistering and erosion, resembling other autoimmune blistering disorders |
| Other Subtypes | Rare variants and subtypes, such as mechanobullous or herpetiform variant and childhood-onset variant |
Diagnosis of Epidermolysis Bullosa Acquisita
Diagnosing epidermolysis bullosa acquisita (EBA) requires a comprehensive evaluation by dermatologists specializing in skin disorders. The diagnosis process involves several steps to accurately identify the condition and differentiate it from other blistering skin disorders.
Clinical Examination
Dermatologists begin the diagnostic process by conducting a thorough clinical examination. They carefully examine the patient’s skin, looking for characteristic features of EBA such as tense blisters, erosions, and scarring. The distribution and location of the blisters can provide important clues for diagnosis.
Laboratory Tests
In addition to the clinical examination, laboratory tests play a crucial role in diagnosing EBA. Blood tests are performed to detect specific autoantibodies associated with the condition, such as anti-type VII collagen antibodies. These antibodies target the proteins that help anchor the layers of the skin together, contributing to blister formation. Identifying these autoantibodies can confirm the diagnosis of EBA.
Histopathological Analysis
A biopsy of the affected skin is usually taken for histopathological analysis. The dermatologist examines the skin tissue under a microscope to identify characteristic features of EBA, such as inflammation, separation of the layers of the skin, and immune deposits. This analysis provides additional evidence to support the diagnosis of EBA.
It is important to note that the diagnosis of EBA requires expertise in dermatology and a multidisciplinary approach. Dermatologists work closely with other healthcare professionals, including rheumatologists and pathologists, to ensure an accurate diagnosis and develop an appropriate treatment plan.
Treatment Options for Epidermolysis Bullosa Acquisita
When it comes to managing epidermolysis bullosa acquisita (EBA), a multidisciplinary approach is essential. Dermatologists, rheumatologists, and other healthcare professionals work together to provide a comprehensive treatment plan tailored to each patient’s needs.
Systemic Therapies:
The mainstay of treatment for EBA involves systemic therapies. These medications target the underlying autoimmune response and help control the symptoms of the skin disorder. Options for systemic treatment include:
- Corticosteroids: Oral or injectable corticosteroids reduce inflammation and blister formation in EBA.
- Immunosuppressants: Medications that suppress the immune system, such as azathioprine and mycophenolate mofetil, can help control EBA symptoms.
- Biologic Therapies: Biologic drugs like rituximab and intravenous immunoglobulins (IVIG) may be used to modulate the immune response in EBA.
Topical Therapies:
In addition to systemic treatments, topical therapies play a crucial role in managing EBA. These medications are applied directly to the affected skin and aim to reduce inflammation, promote wound healing, and prevent infection. Common topical treatments for EBA include:
- Topical Steroids: Corticosteroid creams or ointments help reduce inflammation and itchiness associated with EBA blisters.
- Wound Dressings: Specialized wound dressings, such as hydrocolloids or silicone dressings, create a moist environment that supports healing and protects the skin.
- Antibiotics: Topical antibiotics may be prescribed to prevent or treat bacterial infections that can occur in EBA blistered skin.
A comprehensive treatment plan for EBA may involve a combination of systemic and topical therapies. Regular monitoring and follow-up appointments with healthcare providers are necessary to assess treatment efficacy and make any necessary adjustments.
Managing Epidermolysis Bullosa Acquisita
Effective management of epidermolysis bullosa acquisita (EBA) is crucial in minimizing symptoms and maintaining a good quality of life for individuals with this skin disorder. The management approach for EBA involves a combination of strategies, including lifestyle modifications, wound care, and regular follow-up appointments.
Lifestyle Modifications
Living with EBA requires making certain lifestyle modifications to avoid potential triggers and protect the skin. Some recommendations for managing EBA through lifestyle modifications include:
- Avoiding trauma or friction on the skin that can cause blisters
- Wearing non-irritating clothing and avoiding tight-fitting garments
- Using mild, fragrance-free skincare products
- Protecting the skin from excessive sun exposure
These lifestyle modifications can help minimize flare-ups and reduce the severity of symptoms for individuals with EBA.
Wound Care
Proper wound care is essential in managing EBA and promoting the healing of blisters and skin lesions. It is important to follow the guidance of healthcare professionals in implementing an appropriate wound care routine. Some general recommendations for wound care in EBA include:
- Keeping the affected areas clean and dry
- Gently cleansing blisters and applying sterile dressings
- Avoiding the use of adhesive bandages that may cause further trauma to the skin
- Using moisturizers or emollients to prevent excessive dryness
Healthcare professionals specializing in dermatology can provide personalized recommendations for wound care based on the severity and location of EBA symptoms.
Regular Follow-Up Appointments
Regular follow-up appointments with healthcare providers experienced in treating EBA are crucial for effective management of the condition. These appointments allow for close monitoring of symptoms, adjustment of treatment plans if needed, and evaluation of overall disease progression. During these visits, healthcare professionals may perform necessary tests, such as skin biopsies or blood work, to assess the activity of the autoimmune process and the effectiveness of the current management plan. Regular communication with healthcare providers can help ensure that any changes in symptoms are addressed promptly and that appropriate interventions are implemented.
Comprehensive Management Plan
Managing EBA requires a comprehensive and individualized approach tailored to the specific needs of each patient. This may involve collaborating with various healthcare professionals, such as dermatologists, rheumatologists, and wound care specialists, to create a comprehensive management plan. The plan may include a combination of systemic medications, topical treatments, and supportive therapies to address the underlying autoimmune disease, control symptoms, and promote wound healing.
Overall, effective management of EBA involves a multidisciplinary approach, lifestyle modifications, proper wound care, and regular follow-up appointments. By following a comprehensive management plan, individuals with EBA can improve their quality of life and minimize the impact of this chronic skin disorder.
Research and Advancements in Epidermolysis Bullosa Acquisita
Continued research and advancements are driving progress in understanding and treating epidermolysis bullosa acquisita (EBA), a challenging skin condition. Scientists and healthcare professionals are making breakthroughs in unraveling the underlying mechanisms of EBA, identifying potential therapeutic targets, and exploring novel treatment modalities.
Insights into Pathogenesis
Efforts to unravel the complex pathogenesis of EBA have revealed valuable insights into the underlying mechanisms of this autoimmune skin condition. Researchers are investigating the role of autoantibodies, especially those targeting type VII collagen, in triggering the formation of blisters and determining the disease severity. These discoveries pave the way for better diagnostic methods and targeted therapies.
Potential Therapeutic Targets
The identification of specific molecules and pathways involved in EBA has opened up new avenues for potential therapeutic interventions. Researchers are exploring strategies to modulate immune responses, regulate collagen synthesis, and attenuate blister formation. By targeting these mechanisms, it is hoped that future therapies will offer more effective solutions for managing and treating EBA.
Future Directions for Research
Looking ahead, researchers are actively pursuing further avenues of study to deepen our understanding of EBA. Investigations into the genetic predisposition to EBA and the impact of environmental factors on disease development and progression are underway. Additionally, studies exploring the impact of comorbidities and potential associations with related autoimmune conditions are providing valuable insights into the broader context of EBA.
| Key Research Findings | Contributions to Advancements |
|---|---|
| Identification of autoantibodies targeting type VII collagen | Improved diagnostic methods |
| Exploration of immune modulators and collagen synthesis regulators | Potential new therapeutic strategies |
| Investigation of genetic predisposition and environmental factors | Deeper understanding of disease development and progression |
| Exploration of comorbidities and associations with other autoimmune conditions | Broader context of EBA in relation to related diseases |
The ongoing research and advancements in the field of EBA provide hope for improved diagnosis, management, and treatment options in the future. By building upon these emerging insights, healthcare professionals and researchers are working towards a brighter future for individuals living with this challenging skin condition.
Support and Resources for Epidermolysis Bullosa Acquisita Patients
Living with epidermolysis bullosa acquisita (EBA), a rare autoimmune skin disorder, can be challenging. However, individuals affected by this condition can find support and resources to help navigate their journey. From patient support groups to online communities and advocacy organizations, there are several avenues for support and assistance.
Patient Support Groups
Joining a patient support group can provide individuals with EBA valuable connections and a sense of community. These groups offer opportunities to share experiences, exchange information, and receive emotional support from others who understand the challenges of living with this rare disease. Support group members can provide practical advice on managing symptoms, coping strategies, and navigating the healthcare system.
Online Communities
Online communities dedicated to epidermolysis bullosa acquisita allow individuals to connect with a wider network of people who share similar experiences. These communities often have forums or discussion boards where individuals can ask questions, seek advice, and share updates on their journey. Engaging with online communities can help individuals stay up to date with the latest research and treatment options, as well as find emotional support from others facing similar challenges.
Advocacy Organizations
Several national and international advocacy organizations work tirelessly to raise awareness about epidermolysis bullosa acquisita and provide resources for individuals affected by this rare disease. These organizations offer educational materials, research updates, and access to expert advice. They may also organize awareness campaigns, fundraising events, and conferences, providing opportunities for individuals with EBA to connect with healthcare professionals, researchers, and other patients.
By utilizing these support and resource channels, individuals with epidermolysis bullosa acquisita can gain valuable knowledge, find emotional support, and stay connected to the broader EBA community. With these resources at their disposal, individuals can better navigate their healthcare journey and improve their overall well-being.
Living with Epidermolysis Bullosa Acquisita
Living with epidermolysis bullosa acquisita (EBA) can present various challenges, both physically and emotionally. This chronic skin disorder, characterized by blistering and erosions, can significantly impact an individual’s quality of life. Managing the symptoms and effects of EBA requires a comprehensive approach that addresses the physical discomfort, emotional well-being, and social interactions of those affected.
Physical Challenges
The physical challenges of living with EBA are often the most apparent. The constant presence of blisters and erosions can cause pain, discomfort, and difficulty performing daily activities. The skin requires meticulous care and protection to minimize further damage and prevent infections. Dressings, wound care products, and topical medications recommended by dermatologists can help alleviate symptoms and aid in the healing process.
Furthermore, individuals with EBA may experience limitations in mobility due to the fragility of their skin. Engaging in activities that involve friction or trauma to the skin, such as sports or physical labor, may need to be modified or avoided to prevent exacerbation of symptoms.
Emotional and Psychological Impact
The emotional and psychological impact of living with EBA should not be overlooked. Coping with a chronic, visible skin condition can lead to feelings of self-consciousness, low self-esteem, and social isolation. The unpredictability of flare-ups and the chronicity of the disease can also contribute to anxiety and depression.
It is essential for individuals with EBA to seek emotional support from loved ones, healthcare professionals, and support groups. Sharing experiences, tips, and coping strategies with others who understand the challenges of living with a similar condition can provide validation, encouragement, and a sense of belonging.
Social Aspects
The social aspects of living with EBA can be complex. The visible nature of the symptoms can lead to misconceptions and judgments from others. People with EBA may face discrimination, exclusion, or even ignorance regarding their condition.
Educating family, friends, and colleagues about EBA can help foster understanding, empathy, and support. Participating in advocacy efforts and raising awareness can also contribute to creating a more inclusive and accepting society for those living with EBA and other similar conditions.
Coping Strategies and Improving Quality of Life
While living with EBA poses several challenges, implementing certain coping strategies can help improve quality of life:
- Develop a self-care routine that focuses on gentle skincare practices and wound care management.
- Engage in activities that bring joy and promote overall well-being, such as hobbies, art, or relaxation techniques.
- Seek professional counseling or therapy to address emotional and psychological challenges.
- Connect with support groups or online communities to share experiences and receive support.
- Advocate for yourself and educate others about EBA to promote understanding and acceptance.
By implementing these coping strategies and seeking appropriate support, individuals with EBA can navigate the challenges of living with this autoimmune skin disorder and improve their overall well-being.
| Living with Epidermolysis Bullosa Acquisita: Strategies for Coping and Improving Quality of Life | ||
|---|---|---|
| Physical Challenges | Emotional and Psychological Impact | Social Aspects |
| Management of blisters and erosions | Seeking emotional support | Educating others about EBA |
| Adopting a meticulous skincare routine | Participating in support groups | Advocacy & raising awareness |
| Modifying or avoiding activities that may exacerbate symptoms | Engaging in therapy or counseling |
Prevention and Early Intervention of Epidermolysis Bullosa Acquisita
Preventing and intervening early in epidermolysis bullosa acquisita (EBA) is crucial for managing this chronic skin disorder and improving patient outcomes. By taking proactive measures to minimize triggers, protect the skin, and seek prompt medical care, individuals with EBA can effectively manage their condition and reduce the risk of complications.
Minimizing Triggers
In order to prevent flare-ups and minimize the severity of EBA symptoms, it is important to identify and avoid triggers that can exacerbate the condition. Triggers can vary from person to person, but some common triggers in EBA include:
- Friction or trauma to the skin
- Exposure to sunlight
- Illnesses or infections
- Certain medications
By recognizing and avoiding these triggers, individuals with EBA can greatly reduce the frequency and intensity of blistering episodes.
Protecting the Skin
Proper skin care is essential for individuals with EBA. This includes:
- Gentle cleansing: Using mild, non-irritating cleansers and avoiding harsh soaps or cleansers that can damage the skin.
- Moisturizing: Regularly applying moisturizers to keep the skin hydrated and prevent dryness and cracking.
- Protecting from trauma: Wearing protective clothing, such as soft garments and padding, to minimize friction and reduce the risk of blister formation.
- Sun protection: Applying sunscreen with a high SPF and wearing protective clothing to shield the skin from harmful UV rays.
By adopting these skin care practices, individuals with EBA can help maintain the integrity of their skin and reduce the likelihood of blister formation.
Seeking Prompt Medical Care
Early intervention is crucial in managing EBA. If you suspect you may have symptoms of EBA, it is important to seek medical care from a healthcare professional experienced in diagnosing and treating this rare skin disorder. Prompt and accurate diagnosis allows for the implementation of appropriate treatment strategies and helps prevent complications.
Regular follow-up appointments with your dermatologist or healthcare provider are also essential for monitoring the progression of the condition and adjusting the treatment plan as needed.
By taking proactive steps to prevent and intervene early in EBA, individuals can effectively manage their condition, minimize symptom severity, and improve overall quality of life.
| Prevention and Early Intervention Steps | Benefits |
|---|---|
| Minimizing triggers | Reduces the frequency and intensity of blistering episodes. |
| Protecting the skin | Maintains skin integrity and reduces the risk of blister formation. |
| Seeking prompt medical care | Enables early diagnosis and appropriate treatment to prevent complications. |
Epidermolysis Bullosa Acquisita and Related Conditions
Epidermolysis bullosa acquisita (EBA) is not an isolated skin disorder but rather has connections with other autoimmune diseases and skin disorders. Understanding the relationship between EBA and these related conditions provides important insights into the complexity of autoimmune dermatological conditions.
Autoimmune diseases involve the immune system mistakenly attacking healthy cells and tissues in the body. EBA, as an autoimmune blistering skin disorder, shares similarities with other autoimmune diseases that affect the skin. These include conditions such as pemphigus vulgaris, bullous pemphigoid, and dermatitis herpetiformis.
Pemphigus vulgaris is characterized by blistering and ulceration of the skin and mucous membranes. Similarly, bullous pemphigoid leads to large, fluid-filled blisters that can occur on the skin or within body cavities. Dermatitis herpetiformis is a chronic blistering skin condition associated with gluten intolerance.
Although each of these conditions has its own distinct features and diagnostic criteria, they are all classified as autoimmune diseases affecting the skin. The overlapping symptoms and shared mechanisms underlying the development of these conditions warrant further investigation into their interplay.
Research has shown that individuals with autoimmune diseases are more likely to develop other autoimmune disorders, which includes a potential association between EBA and other autoimmune skin conditions. Understanding these connections can aid in the diagnosis and management of patients, as well as shed light on potential common genetic and environmental factors that contribute to the development of these disorders.
| Autoimmune Disease/Skin Disorder | Similarities with EBA | Distinguishing Features |
|---|---|---|
| Pemphigus vulgaris | Autoimmune blistering disorder affecting the skin and mucous membranes | Formation of characteristic intraepithelial blisters and immunoglobulin G (IgG) antibodies targeting desmoglein proteins |
| Bullous pemphigoid | Autoimmune blistering disorder characterized by large, tense blisters and eosinophilic infiltrates | IgG and complement deposition along the basement membrane zone |
| Dermatitis herpetiformis | Chronic blistering skin condition associated with gluten intolerance (celiac disease) | Presence of granular immunoglobulin A (IgA) deposits in the dermal papillae |
Investigating the shared mechanisms and key differences between EBA and related conditions can lead to advancements in understanding their pathogenesis and developing effective treatment strategies. It is crucial for healthcare professionals to consider the possibility of coexisting autoimmune diseases or skin disorders when diagnosing and managing individuals with EBA, as this knowledge can help guide comprehensive care plans.
Continued research and collaboration among dermatologists, immunologists, and other healthcare specialists are essential in unraveling the complexities of autoimmune diseases and skin disorders, including their interconnectedness with EBA. Together, we can make significant strides in improving the lives of those affected by these conditions.
Conclusion
Epidermolysis bullosa acquisita (EBA) is a rare autoimmune skin disorder characterized by blistering of the skin. Throughout this article, we have explored the various aspects of this condition, including its symptoms, types, diagnosis, treatment options, and management strategies. It is crucial to emphasize the significance of early diagnosis, proper management, and access to support for individuals with EBA.
Seeking medical guidance from reputable healthcare institutions, such as Acibadem Healthcare Group, is essential for accurate diagnosis and effective treatment. Dermatologists play a vital role in diagnosing EBA and developing comprehensive management plans tailored to each patient’s needs. Additionally, a multidisciplinary approach involving other healthcare professionals, such as rheumatologists, is crucial for optimal outcomes.
Living with EBA can be challenging, both physically and emotionally. However, with proper care, support, and lifestyle modifications, individuals with EBA can improve their quality of life. By staying informed, connecting with patient support groups, and utilizing available resources, individuals with EBA can navigate the challenges they may face.
If you or someone you know is experiencing symptoms or concerns related to epidermolysis bullosa acquisita, it is important to seek medical attention promptly. Early intervention can help prevent complications and ensure the best possible outcomes for individuals with this rare skin disorder.
FAQ
What is epidermolysis bullosa acquisita?
Epidermolysis bullosa acquisita (EBA) is a rare autoimmune skin disorder that causes blistering and damage to the skin and mucous membranes. It is characterized by the production of antibodies that target specific proteins within the skin, leading to inflammation and blister formation.
What causes epidermolysis bullosa acquisita?
The exact cause of epidermolysis bullosa acquisita is not fully understood. However, it is believed to be an autoimmune disease, where the body's immune system mistakenly attacks its own tissues. Certain genetic and environmental factors may contribute to the development of EBA, although further research is needed to determine the exact triggers.
What are the symptoms of epidermolysis bullosa acquisita?
The main symptom of epidermolysis bullosa acquisita is the formation of blisters on the skin and mucous membranes, often triggered by minor trauma or friction. These blisters can be painful and may lead to scarring and skin thickening. Other common symptoms include itching, redness, and difficulty healing wounds.
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