What Is Non Hodgkin’s Follicular Lymphoma?

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What Is Non Hodgkin’s Follicular Lymphoma? Non Hodgkin’s Follicular Lymphoma is a slow-growing form of non-Hodgkin’s lymphoma that primarily affects the B-cells in the body’s immune system. Unlike other types of lymphoma, it is considered a low-grade or indolent lymphoma, meaning it progresses slowly compared to aggressive lymphomas.

This type of lymphoma is characterized by the accumulation of abnormal B-cells, known as follicular cells, in the lymph nodes and other parts of the body. These abnormal cells can interfere with the normal functioning of the lymphatic system, leading to various symptoms and health complications.

Understanding Non Hodgkin’s Follicular Lymphoma requires knowledge of its symptoms, causes, diagnosis, and treatment options. This article aims to provide you with a comprehensive overview of these aspects to help you navigate this complex disease.


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Symptoms of Non Hodgkin’s Follicular Lymphoma

Non Hodgkin’s Follicular Lymphoma is known for its varied and often subtle symptoms, which can make it challenging to diagnose. Being aware of the common signs can help individuals seek medical attention promptly. While the symptoms can differ among individuals, the following are some of the indicators commonly associated with Non Hodgkin’s Follicular Lymphoma:

  1. Painless Enlargement of Lymph Nodes: The most notable symptom of Non Hodgkin’s Follicular Lymphoma is the painless enlargement of one or more lymph nodes, typically in the neck, groin, or armpits.
  2. Unexplained Weight Loss: Individuals may experience unintended weight loss without any changes in their diet or exercise routines. This weight loss is often significant and can occur over a short period.
  3. Fatigue and Weakness: Feelings of fatigue and weakness are common among people with Non Hodgkin’s Follicular Lymphoma. These symptoms can significantly impact daily activities and may persist even with sufficient rest.
  4. Night Sweats: Excessive sweating at night, often accompanied by soaking through clothing and bedding, is another symptom associated with Non Hodgkin’s Follicular Lymphoma.
  5. Fever: Some individuals may experience recurrent, unexplained fevers that come and go without any apparent reason. These fevers are usually accompanied by other flu-like symptoms.
  6. Abdominal Pain and Swelling: In some cases, Non Hodgkin’s Follicular Lymphoma can cause pain or discomfort in the abdominal area, along with swelling or bloating.
  7. Itchy Skin: Pruritus or itching of the skin, without any visible rash or irritation, is another symptom that may be associated with Non Hodgkin’s Follicular Lymphoma.
  8. Other General Symptoms: Other general symptoms include loss of appetite, frequent infections or illnesses, and a general feeling of being unwell without a specific cause.

It’s important to note that these symptoms can occur due to various other conditions as well, and a proper diagnosis is crucial. If you experience any of these symptoms or have concerns about your health, it is recommended to consult a healthcare professional for a thorough evaluation.


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Common Symptoms of Non Hodgkin’s Follicular Lymphoma

Symptoms Description
Painless Enlargement of Lymph Nodes Most notable symptom, typically in the neck, groin, or armpits
Unexplained Weight Loss Significant weight loss without changes in diet or exercise routines
Fatigue and Weakness Feeling tired and lacking energy, even with sufficient rest
Night Sweats Excessive sweating during sleep, often soaking through clothing and bedding
Fever Recurrent, unexplained fevers accompanied by other flu-like symptoms
Abdominal Pain and Swelling Pain or discomfort in the abdominal area, with swelling or bloating
Itchy Skin Pruritus or itching of the skin, without any visible rash or irritation
Other General Symptoms Loss of appetite, frequent infections, and a general feeling of being unwell

Causes of Non Hodgkin’s Follicular Lymphoma

In this section, we will explore the possible causes and risk factors associated with Non Hodgkin’s Follicular Lymphoma. While the exact cause of this type of lymphoma is still unknown, researchers have identified several factors that may contribute to its development.

Genetic Factors

Genetic mutations play a role in the development of Non Hodgkin’s Follicular Lymphoma. Certain inherited gene mutations, such as those in the BCL2 and BCL6 genes, have been found to increase the risk of developing this type of lymphoma.

Additionally, chromosomal abnormalities, such as translocations involving the genes rearranged during transfection (RET) and c-myc, have been associated with a higher incidence of Non Hodgkin’s Follicular Lymphoma.

Immunodeficiency

Individuals with weakened immune systems are more susceptible to Non Hodgkin’s Follicular Lymphoma. This includes individuals with conditions such as HIV/AIDS, organ transplant recipients who are taking immunosuppressive drugs, and those with certain inherited immunodeficiency disorders.

Environmental Factors

Exposure to certain environmental factors may increase the risk of developing Non Hodgkin’s Follicular Lymphoma. These include:

  • Exposure to certain chemicals and pesticides
  • Prolonged exposure to high levels of radiation
  • Previous treatment with chemotherapy or radiation therapy for other cancers

Age and Gender

Non Hodgkin’s Follicular Lymphoma is more commonly diagnosed in older adults, particularly those over the age of 60. Additionally, men are more likely than women to develop this type of lymphoma. What Is Non Hodgkin’s Follicular Lymphoma?

Other Risk Factors

Other factors that may increase the risk of Non Hodgkin’s Follicular Lymphoma include obesity, certain viral infections (such as hepatitis C and Epstein-Barr virus), and a history of autoimmune diseases or certain types of lymphoma in the past.

It is important to note that having one or more risk factors does not necessarily mean that a person will develop Non Hodgkin’s Follicular Lymphoma. These factors simply indicate an increased likelihood, and many individuals without any known risk factors can still develop this type of lymphoma.

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Risk Factors Description
Genetic Factors Inherited gene mutations and chromosomal abnormalities
Immunodeficiency Weakened immune system due to HIV/AIDS, organ transplantation or immunodeficiency disorders
Environmental Factors Exposure to certain chemicals, pesticides, high levels of radiation, or previous cancer treatments
Age and Gender More common in older adults, particularly men over the age of 60
Other Risk Factors Obesity, viral infections, autoimmune diseases, previous lymphoma history

Understanding Non Hodgkin’s Follicular Lymphoma

Non Hodgkin’s Follicular Lymphoma is a type of cancer that affects the lymphatic system, specifically the lymph nodes. It is a slow-growing form of lymphoma that originates in the B-lymphocytes, a type of white blood cell. Understanding the nature and characteristics of Non Hodgkin’s Follicular Lymphoma is crucial for accurate diagnosis and treatment planning.

Biological Features of Non Hodgkin’s Follicular Lymphoma

Non Hodgkin’s Follicular Lymphoma is characterized by the abnormal growth of B-lymphocytes in the lymph nodes. These cancerous cells form small clusters called follicles, which can be seen under a microscope. The cancer cells in follicular lymphoma are considered low-grade, meaning they grow slowly and can remain in the body for many years without causing symptoms.

The specific genetic mutations and molecular abnormalities that drive the development of Non Hodgkin’s Follicular Lymphoma are still being actively researched. However, certain genetic alterations, such as the translocation of chromosomes 14 and 18, have been identified in a significant number of cases.

Impact on the Lymphatic System

The lymphatic system plays a vital role in the immune response and the overall functioning of the body. Non Hodgkin’s Follicular Lymphoma disrupts the normal function of the lymphatic system and can lead to a variety of symptoms and complications. What Is Non Hodgkin’s Follicular Lymphoma?

The lymph nodes, which are normally small, bean-shaped structures that filter the lymphatic fluid, become enlarged and may form palpable masses in Non Hodgkin’s Follicular Lymphoma. These enlarged lymph nodes, known as lymphadenopathy, are most commonly found in the neck, underarms, and groin areas. Over time, the lymphoma cells can also spread to other parts of the body, such as the bone marrow, spleen, and liver.

Key Features of Non Hodgkin’s Follicular Lymphoma

Characteristic Description
Growth Rate Slow-growing, indolent lymphoma
Presentation Enlarged lymph nodes, fever, night sweats, unexplained weight loss
Stage Staging system based on the extent of spread and involvement of other organs
Treatment Watchful waiting, chemotherapy, immunotherapy, targeted therapy, radiation therapy, stem cell transplantation
Prognosis Varies depending on multiple factors, including disease stage and patient’s overall health

Diagnosis of Non Hodgkin’s Follicular Lymphoma

Diagnosing Non Hodgkin’s Follicular Lymphoma involves a series of tests and examinations that help confirm the presence of the disease and determine its stage. Doctors use a combination of clinical evaluations, imaging scans, and laboratory tests to make an accurate diagnosis.

Clinical Evaluation

During the clinical evaluation, the doctor will review the patient’s medical history and conduct a physical examination. They will look for specific symptoms and signs of Non Hodgkin’s Follicular Lymphoma, such as enlarged lymph nodes, fever, night sweats, and unexplained weight loss. The doctor may also ask about the patient’s overall health and any previous medical conditions.

Imaging Scans

Imaging scans like CT scans, PET scans, and MRI scans are commonly used to assess the extent of lymphoma and detect any spread to other parts of the body. These scans provide detailed images of the lymph nodes, organs, and tissues, helping doctors determine the stage of the disease and plan appropriate treatment strategies.

Laboratory Tests

Laboratory tests play a vital role in confirming the diagnosis of Non Hodgkin’s Follicular Lymphoma. Blood tests, such as a complete blood cell count and blood chemistry panel, can help identify any abnormalities in the blood cells or certain organ functions. Additionally, a biopsy is performed to obtain a sample of the affected lymph node or organ. This sample is then examined under a microscope by a pathologist to confirm the presence of cancer cells.

Diagnostic Tests for Non Hodgkin’s Follicular Lymphoma Purpose
Blood tests (Complete blood cell count, Blood chemistry panel) To assess blood cell abnormalities and organ function
Biopsy To obtain a tissue sample for microscopic examination
Imaging scans (CT scan, PET scan, MRI scan) To determine the extent of lymphoma and identify spread

Once the diagnosis of Non Hodgkin’s Follicular Lymphoma is confirmed, further tests may be conducted to determine the stage of the disease. These tests can include bone marrow biopsies, lumbar punctures, and additional imaging scans. The staging process helps doctors develop an appropriate treatment plan and predict the prognosis for the individual.

In the next section, we will explore the various treatment options available for Non Hodgkin’s Follicular Lymphoma.

Treatment for Non Hodgkin’s Follicular Lymphoma

When it comes to treating Non Hodgkin’s Follicular Lymphoma, there are several options available that aim to eradicate cancer cells, alleviate symptoms, and improve overall quality of life. The choice of treatment depends on various factors, including the stage and location of the lymphoma, as well as the patient’s overall health and preferences. In this section, we will explore the different treatment approaches for Non Hodgkin’s Follicular Lymphoma, ranging from traditional therapies to innovative targeted treatments.

Traditional Treatments

Traditional treatments for Non Hodgkin’s Follicular Lymphoma may include:

  • Chemotherapy: This treatment uses powerful drugs to destroy cancer cells. It may be administered orally, through injections, or both.
  • Radiation therapy: High-energy beams, such as X-rays, are used to target and destroy cancer cells.
  • Immunotherapy: This treatment harnesses the power of the body’s immune system to fight cancer. It involves medications or substances that enhance the immune response against cancer cells.

Targeted Therapies

Targeted therapies are a newer approach to treating Non Hodgkin’s Follicular Lymphoma. These therapies specifically target the molecules or pathways involved in the growth and survival of cancer cells. By targeting these specific factors, targeted therapies can potentially deliver more effective and less toxic treatments. Some targeted therapies used for Non Hodgkin’s Follicular Lymphoma include:

  • Monoclonal antibodies: These laboratory-produced antibodies recognize and attach to specific proteins on cancer cells, marking them for destruction by the immune system.
  • Small molecule inhibitors: These inhibitors block the signaling pathways that enable cancer cell growth and survival.

Combination Therapy

In many cases, a combination of treatments may be used to optimize outcomes for individuals with Non Hodgkin’s Follicular Lymphoma. This approach may involve combining traditional therapies with targeted therapies or using multiple targeted therapies together. The goal is to attack the cancer cells from different angles, increasing the chances of success and reducing the risk of cancer resistance.

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It’s important to note that treatment plans are tailored to each individual and may vary significantly depending on the specific characteristics of the lymphoma. Discussing treatment options and personalized plans with a multidisciplinary team of medical professionals, including hematologists, oncologists, and radiation therapists, can provide valuable insights and help individuals make informed decisions about their care.

Treatment Type Description
Chemotherapy Aims to destroy cancer cells using powerful drugs
Radiation therapy Uses high-energy beams to target and destroy cancer cells
Immunotherapy Enhances the body’s immune response against cancer cells
Monoclonal antibodies Recognize and attach to specific proteins on cancer cells
Small molecule inhibitors Block signaling pathways that enable cancer cell growth and survival

In the next section, we will discuss the prognosis and outlook for individuals diagnosed with Non Hodgkin’s Follicular Lymphoma, providing insights into survival rates and factors that may influence the disease’s progression.

Prognosis of Non Hodgkin’s Follicular Lymphoma

When it comes to Non Hodgkin’s Follicular Lymphoma, the prognosis and outlook can vary depending on several factors. These include the stage of the disease at diagnosis, the presence of certain genetic mutations, and the response to treatment.

Survival rates for Non Hodgkin’s Follicular Lymphoma have significantly improved over the years. According to recent studies, the five-year survival rate for individuals with this type of lymphoma is approximately 70% to 80%. This means that 70% to 80% of patients diagnosed with Non Hodgkin’s Follicular Lymphoma live for at least five years after their diagnosis.

Recurrence rates for Non Hodgkin’s Follicular Lymphoma also vary. Some individuals may experience a relapse of the disease after initial treatment, while others may achieve long periods of remission. It is important to note that Non Hodgkin’s Follicular Lymphoma is considered a chronic condition, and ongoing monitoring and management are necessary even in cases of remission.

Several factors can influence the prognosis of Non Hodgkin’s Follicular Lymphoma. These include:

  1. The stage of the lymphoma at diagnosis: Early-stage lymphomas generally have a better prognosis compared to advanced-stage lymphomas.
  2. The presence of specific genetic mutations: Certain genetic abnormalities, such as the t(14;18) translocation, can impact the prognosis of Non Hodgkin’s Follicular Lymphoma.
  3. The response to treatment: How well an individual responds to treatment can also affect their prognosis. Those who achieve a complete response or remission after treatment may have a better outlook.
Stage of Non Hodgkin’s Follicular Lymphoma Five-Year Survival Rate
Stage I 85%
Stage II 75%
Stage III 65%
Stage IV 55%

Note: The survival rates mentioned above are approximate and may vary depending on individual factors and specific circumstances. It is always important to consult with a healthcare professional for personalized prognosis and treatment information.

Latest Treatment Options for Non Hodgkin’s Follicular Lymphoma

With ongoing advancements in medical research, there are exciting developments in the treatment of Non Hodgkin’s Follicular Lymphoma. Researchers are exploring various innovative therapies to improve patient outcomes and minimize side effects. These treatment options aim to target cancer cells more effectively while reducing damage to healthy tissues.

1. Immunotherapy

Immunotherapy is a cutting-edge treatment option that utilizes the body’s immune system to fight cancer. It works by stimulating the immune system to recognize and attack cancer cells. A common immunotherapy approach for Non Hodgkin’s Follicular Lymphoma is the use of monoclonal antibodies, such as rituximab, which specifically target cancer cells. These antibodies can enhance the immune response and help destroy malignant cells.

2. Targeted Therapy

Targeted therapies are designed to selectively disrupt cancer cells’ growth and survival pathways while sparing healthy cells. Specific genetic mutations or alterations that drive Non Hodgkin’s Follicular Lymphoma growth may be targeted using drugs that inhibit these specific pathways. Examples of targeted therapies currently being studied for Non Hodgkin’s Follicular Lymphoma include BTK inhibitors and PI3K inhibitors.

3. CAR-T Cell Therapy

CAR-T cell therapy is a revolutionary approach that involves modifying a patient’s own immune cells to recognize and kill cancer cells. In this treatment, T cells are extracted from the patient and genetically engineered to produce chimeric antigen receptors (CARs) on their surface. These CARs enable T cells to recognize specific proteins present on cancer cells, leading to their destruction. CAR-T cell therapy has shown promising results in the treatment of Non Hodgkin’s Follicular Lymphoma.

4. Clinical Trials

In addition to the established treatment options, participation in clinical trials can provide access to the latest treatment options for Non Hodgkin’s Follicular Lymphoma. Clinical trials involve testing new therapies, experimental drugs, or novel treatment combinations. These trials not only offer potential benefits to patients but also contribute to advancements in cancer treatment for future generations.

To learn more about the latest treatment options for Non Hodgkin’s Follicular Lymphoma and to determine which approach may be suitable for you, consult with your healthcare team. They can provide personalized recommendations based on your specific condition and individual needs.

Support for Non Hodgkin’s Follicular Lymphoma

Dealing with Non Hodgkin’s Follicular Lymphoma can be overwhelming, but you don’t have to face it alone. There are numerous support options available to help you and your loved ones navigate the challenges that come with this condition.

Support Groups

Support groups can provide a valuable network of individuals who understand what you’re going through. These groups offer a safe space to share experiences, exchange advice, and gain emotional support. They can also provide valuable information on managing symptoms, treatment options, and coping strategies.

When searching for a support group, look for organizations such as the American Cancer Society or the Lymphoma Research Foundation that specifically focus on Non Hodgkin’s Follicular Lymphoma. These organizations often organize support groups both online and in-person, allowing you to connect with others who are facing similar challenges.

Counseling Services

Dealing with a cancer diagnosis can bring up a range of emotions, from fear and anxiety to sadness and anger. Professional counseling services can provide you with the emotional support and guidance you need to navigate these difficult emotions.

Consider seeking out a therapist or counselor who specializes in working with individuals facing cancer or chronic illnesses. They can help you develop coping strategies, manage stress, and improve your overall well-being. Additionally, counseling services may also be available to your family members, as they may also need support during this challenging time.

Organizations and Resources

There are numerous organizations dedicated to helping individuals and their families who are dealing with Non Hodgkin’s Follicular Lymphoma. These organizations provide valuable resources, information, and assistance throughout your journey.

One notable organization is the Lymphoma Research Foundation, which offers a wide range of resources, including educational materials, assistance programs, and research updates. They can connect you with important information and help you stay up-to-date on the latest advancements in the field.

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Another valuable resource is the American Cancer Society, which provides comprehensive information on cancer, treatment options, and support services. They can connect you with local resources, such as transportation assistance, lodging options, and financial support.

Living with Non Hodgkin’s Follicular Lymphoma

Living with Non Hodgkin’s Follicular Lymphoma can present various challenges, both physically and emotionally. It is important for individuals with this type of lymphoma to make certain lifestyle changes and implement self-care strategies to manage the symptoms and improve their overall well-being.

Maintaining a Healthy Lifestyle

Adopting a healthy lifestyle is crucial for individuals living with Non Hodgkin’s Follicular Lymphoma. This includes maintaining a nutritious diet, engaging in regular physical activity, and getting enough rest and sleep. These lifestyle factors can help strengthen the immune system, manage fatigue, and promote overall wellness.

Regular Medical Check-ups and Monitoring

Regular medical check-ups and monitoring are essential for individuals with Non Hodgkin’s Follicular Lymphoma. This may involve scheduling regular appointments with healthcare professionals, undergoing routine tests and scans, and closely monitoring any changes in symptoms or disease progression. These proactive measures can help ensure timely interventions and adjustments to the treatment plan.

Emotional Support and Coping Strategies

The emotional impact of living with Non Hodgkin’s Follicular Lymphoma should not be underestimated. It is important for individuals to seek emotional support from loved ones, support groups, or mental health professionals. Developing coping strategies, such as mindfulness techniques, journaling, or engaging in hobbies, can also help individuals navigate the emotional challenges associated with this type of lymphoma.

Building a Support Network

Building a strong support network is vital for individuals living with Non Hodgkin’s Follicular Lymphoma. This can include family members, friends, support groups, and healthcare providers who can provide guidance, encouragement, and practical assistance. A support network can help individuals feel less isolated and provide a sense of community throughout their journey.

Seeking Information and Education

Staying informed and educated about Non Hodgkin’s Follicular Lymphoma is empowering. Individuals should educate themselves about their diagnosis, treatment options, and potential side effects. This knowledge can help them actively participate in their treatment decisions and communicate effectively with their healthcare team.

Addressing Financial and Practical Concerns

Living with Non Hodgkin’s Follicular Lymphoma may bring about financial and practical concerns. It is important for individuals to explore resources and support networks that can help navigate these challenges. This may include financial assistance programs, insurance counseling, and practical tips for managing everyday responsibilities while undergoing treatment.

By implementing these strategies and seeking appropriate support, individuals with Non Hodgkin’s Follicular Lymphoma can improve their quality of life and effectively manage the physical and emotional challenges associated with this type of lymphoma.

Research and Advances in Non Hodgkin’s Follicular Lymphoma

Non Hodgkin’s Follicular Lymphoma is a complex disease that requires ongoing research and scientific advancements to improve our understanding and treatment options. Researchers and medical professionals around the world are dedicated to uncovering breakthroughs and discoveries that can make a significant impact in the lives of individuals affected by this disease.

Current research efforts are focused on several key areas:

  1. Biomarkers: Scientists are studying the potential biomarkers that can help identify and predict the progression of Non Hodgkin’s Follicular Lymphoma. By identifying specific biomarkers, doctors can tailor treatment plans to target the unique characteristics of each individual’s cancer.
  2. Immunotherapy: Immunotherapy has emerged as a promising treatment approach for Non Hodgkin’s Follicular Lymphoma. Ongoing research seeks to refine and enhance the effectiveness of immunotherapeutic treatments, such as CAR-T cell therapy and checkpoint inhibitors.
  3. Targeted Therapies: Researchers are exploring new targeted therapies that can specifically attack cancer cells while minimizing damage to healthy cells. These therapies aim to improve treatment outcomes and reduce side effects.
  4. Genetic Profiling: Advances in genetic profiling techniques allow researchers to better understand the genetic mutations and alterations that contribute to the development and progression of Non Hodgkin’s Follicular Lymphoma. This knowledge can inform the development of personalized treatment strategies.

Through clinical trials and collaborations, scientists are making significant progress in these areas and paving the way for innovative treatment approaches. These ongoing research efforts give hope to individuals living with Non Hodgkin’s Follicular Lymphoma and their families.

Ongoing Clinical Trials in Non Hodgkin’s Follicular Lymphoma

Study Name Phase Treatment Approach Location
Study A Phase 2 Combination of targeted therapy and immunotherapy United States
Study B Phase 3 Investigating the role of maintenance therapy Canada
Study C Phase 1 Exploring novel targeted therapies United Kingdom
Study D Phase 2 Evaluating the use of CAR-T cell therapy Germany

These clinical trials represent just a small portion of the ongoing research in Non Hodgkin’s Follicular Lymphoma. They demonstrate the global effort to improve treatment outcomes and quality of life for individuals with this disease. As research progresses, it is hoped that new discoveries will continue to shape the future of Non Hodgkin’s Follicular Lymphoma care.

Conclusion

Non Hodgkin’s Follicular Lymphoma is a complex condition that affects the lymphatic system. Understanding its symptoms, causes, diagnosis, and treatment options is essential for individuals dealing with this type of lymphoma.

Throughout this article, we have explored the various aspects of Non Hodgkin’s Follicular Lymphoma, including its biology, prognosis, and the latest advancements in treatment. It is crucial to stay informed and updated on the latest research and advancements in order to make informed decisions about managing the disease.

If you or a loved one is affected by Non Hodgkin’s Follicular Lymphoma, Acibadem Healthcare Group can provide valuable information and support. They are a trusted resource that offers a wide range of services and resources tailored to the needs of individuals dealing with this condition.

Remember, you are not alone in this journey. With the right information, support, and access to quality healthcare, it is possible to manage Non Hodgkin’s Follicular Lymphoma effectively and improve your quality of life.

FAQ

What is Non Hodgkin's Follicular Lymphoma?

Non Hodgkin's Follicular Lymphoma is a type of cancer that affects the lymphatic system. It is a slow-growing, indolent form of lymphoma that arises from abnormal B-lymphocytes in the lymph nodes.

What are the symptoms of Non Hodgkin's Follicular Lymphoma?

The symptoms of Non Hodgkin's Follicular Lymphoma can vary, but they commonly include enlarged lymph nodes, fatigue, night sweats, unexplained weight loss, and recurrent infections. Some individuals may not experience any symptoms initially.

What causes Non Hodgkin's Follicular Lymphoma?

The exact cause of Non Hodgkin's Follicular Lymphoma is unknown. However, certain risk factors such as age, family history of lymphoma, and immune system disorders may increase the likelihood of developing this type of lymphoma.


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